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Article

Variant rs17619600 in the gene encoding serotonin receptor 2B (HTR2B) increases the risk of gestational diabetes mellitus: a case-control study.

European journal of medical research - 21 Jul 2023

Penno Juliana Regina Chamlian Zucare, Santos-Bezerra Daniele Pereira, Cavaleiro Ana Mercedes, da Silva Sousa Ana Maria, Zaccara Tatiana Assunção, da Costa Rafaela Alkmin, Francisco Rossana Pulcineli Vieira, Correa-Giannella Maria Lucia

Abstract excerpt

BACKGROUND: During pregnancy, the increase in maternal insulin resistance is compensated by hyperplasia and increased function of maternal pancreatic beta cells; the failure of this compensatory mechanism is associated with gestational diabetes mellitus (GDM). Serotonin participates in beta cell adaptation, acting downstream of the prolactin pathway; the blocking of serotonin receptor B (HTR2B) signaling in...

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PMID: 37480094
DOI: 10.1186/s40001-023-01211-6
PMCID: PMC10362639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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