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Article

RAGE/SNAIL1 signaling drives epithelial-mesenchymal plasticity in metastatic triple-negative breast cancer.

Oncogene - 1 Aug 2023

Pujals Mireia, Mayans Carla, Bellio Chiara, Méndez Olga, Greco Emanuela, Fasani Roberta, Alemany-Chavarria Mercè, Zamora Esther, Padilla Laura, Mitjans Francesc, Nuciforo Paolo, Canals Francesc, Nonell Lara, Abad María, Saura Cristina, Tabernero Josep, Villanueva Josep

Abstract excerpt

Epithelial/Mesenchymal (E/M) plasticity plays a fundamental role both in embryogenesis and during tumorigenesis. The receptor for advanced glycation end products (RAGE) is a driver of cell plasticity in fibrotic diseases; however, its role and molecular mechanism in triple-negative breast cancer (TNBC) remains unclear. Here, we demonstrate that RAGE signaling maintains the mesenchymal phenotype of aggressive TNBC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37468678
DOI: 10.1038/s41388-023-02778-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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