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Article

Evolution under a model of functionally buffered deleterious mutations can lead to positive selection in protein-coding genes.

Evolution; international journal of organic evolution - 3 Oct 2023

Shen Runxi, Wenzel Miwa, Messer Philipp W, Aquadro Charles F

Abstract excerpt

Selective pressures on DNA sequences often result in departures from neutral evolution that can be captured by the McDonald-Kreitman (MK) test. However, the nature of such selective forces often remains unknown to experimentalists. Amino acid fixations driven by natural selection in protein-coding genes are commonly associated with a genetic arms race or changing biological purposes, leading to proteins with new...

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Identifiers

PMID: 37464886
DOI: 10.1093/evolut/qpad131
PMCID: PMC10547125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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