Function-specific accelerations in rates of sequence evolution suggest predictable epistatic responses to reduced effective population size.

Abstract excerpt

Changes in effective population size impinge on patterns of molecular evolution. Notably, slightly deleterious mutations are more likely to drift to fixation in smaller populations, which should typically also lead to an overall acceleration in the rates of evolution. This prediction has been validated empirically for several endosymbiont and island taxa. Here, we first show that rate accelerations are also...

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