Article
Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2004
Huber Samuel, Schramm Christoph, Lehr Hans A, Mann Amrit, Schmitt Steffen, Becker Christoph, Protschka Martina, Galle Peter R, Neurath Markus F, Blessing Manfred
Abstract excerpt
Data regarding the role of TGF-beta for the in vivo function of regulatory CD4(+)CD25(+) T cells (Treg) are controversial. A transgenic mouse model with impaired TGF-beta signaling specifically in T cells was used to assess the role of endogenous TGF-beta for the in vivo function of CD4(+)CD25(+) Treg in a murine model of colitis induced by dextran sulfate. Transfer of wild-type, but not transgenic CD4(+)CD25(+)...
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