Double heterozygous germline pathogenic variants in patients referred to a tertiary cancer genetics clinic in Singapore

Abstract excerpt

Background The increasing use of multigene panel testing has led to a rise in the identification of double heterozygous (DH) pathogenic variants in cancer patients, although their frequency and clinical relevance remain poorly characterised, particularly in Asian populations. Methods We conducted a retrospective review of 5,178 patients referred to a tertiary cancer genetics clinic in Singapore. DH pathogenic vari...

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• BRCA gene mutations in cancer
• Genetic factors in colorectal cancer
• Genomics and Rare Diseases

Identifiers and source

Literature Corpus work

004f12a5-fe37-537e-b27f-4be7815eabc7

DOI

10.3389/fonc.2026.1903384