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Article

Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers.

PloS one - 1 Jan 2018

Pritchard Antonia L, Johansson Peter A, Nathan Vaishnavi, Howlie Madeleine, Symmons Judith, Palmer Jane M, Hayward Nicholas K

Abstract excerpt

BACKGROUND: While a number of autosomal dominant and autosomal recessive cancer syndromes have an associated spectrum of cancers, the prevalence and variety of cancer predisposition mutations in patients with multiple primary cancers have not been extensively investigated. An understanding of the variants predisposing to more than one cancer type could improve patient care, including screening and genetic...

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Identifiers

PMID: 29641532
DOI: 10.1371/journal.pone.0194098
PMCID: PMC5894988

Genes

JAK1
JAK2
POLE2
ROS1
SRSF2
TET2
TYK2

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