Article
A TGF-β-dominant chemoresistant phenotype of hepatoblastoma associated with aflatoxin exposure in children.
Hepatology (Baltimore, Md.) - 1 Mar 2024
Xiang Xiao, Hao Yijie, Cheng Cheng, Hu Huanjing, Chen Huadong, Tan Jiehui, Wang Yuanqi, Liu Xiaofei, Peng Bo, Liao Junbin, Wang Ji, Xie Yubin, Liu Juncheng, Chen Shuling, Xu Lixia, Xie Wenxuan, Xue Ruidong, Kuang Ming, Xu Zhe, Jiang Hong, Peng Sui
Abstract excerpt
BACKGROUND AND AIMS: Hepatoblastoma (HB) is the most common liver cancer in children, posing a serious threat to children's health. Chemoresistance is the leading cause of mortality in patients with HB. A more explicit definition of the features of chemotherapy resistance in HB represents a fundamental urgent need. APPROACH AND RESULTS: We performed an integrative analysis including single-cell RNA sequencing,...
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