Article
BRAF testing modalities in histiocytic disorders: Comparative analysis and proposed testing algorithm.
American journal of clinical pathology - 2 Nov 2023
Acosta-Medina Aldo A, Abeykoon Jithma P, Go Ronald S, Goyal Gaurav, Ravindran Aishwarya, Schram Susan M, Rech Karen L
Abstract excerpt
OBJECTIVES: Understanding of histiocytic disorders has been revolutionized by demonstration of mitogen-activated protein kinase (MAPK) pathway mutations, most commonly BRAFV600E. The optimal testing strategy to assess BRAFV600E is unknown. We aimed to compare performance of testing modalities, to propose a framework for evaluation of BRAFV600E mutation status in histiocytic disorders. METHODS: We retrospectively...
Topics
- Humans
- Proto-Oncogene Proteins B-raf
- Retrospective Studies
- Mutation
- Sensitivity and Specificity
- Algorithms