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Hereditary breast and ovarian cancer: from genes to molecular targeted therapies.

Critical reviews in clinical laboratory sciences - 1 Dec 2023

Ponti Giovanni, De Angelis Carmine, Ponti Rosamaria, Pongetti Linda, Losi Lorena, Sticchi Alberto, Tomasi Aldo, Ozben Tomris

Abstract excerpt

Hereditary familial tumors constitute 10-15% of all malignancies and present opportunities for the identification of therapeutic approaches against specific germline genetic defects. Hereditary breast and ovarian cancer (HBOC) syndrome, which is linked to the pathogenic mutations of the breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) genes, is an important research model for personalized therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37455374
DOI: 10.1080/10408363.2023.2234488

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