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Article

ZBTB40 is a telomere-associated protein and protects telomeres in human ALT cells

14 Jul 2023

Abstract excerpt

Alternative lengthening of telomeres (ALTs) mechanism is activated in some somatic, germ cells, and human cancer cells. However, the key regulators and mechanisms of the ALT pathway remain elusive. Here we demonstrated that ZBTB40 is a novel telomere-associated protein and binds to telomeric dsDNA through its N-terminal BTB (BR-C, ttk and bab) or POZ (Pox virus and Zinc finger) domain in ALT cells. Notably, the...

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PMID: 37454741
DOI: 10.1016/j.jbc.2023.105053

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