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Article

Optimizing genetic circuits by global sensitivity analysis.

Biophysical journal - 1 Oct 2004

Feng Xiao-Jiang, Hooshangi Sara, Chen David, Li Genyuan, Weiss Ron, Rabitz Herschel

Abstract excerpt

Artificial genetic circuits are becoming important tools for controlling cellular behavior and studying molecular biosystems. To genetically optimize the properties of complex circuits in a practically feasible fashion, it is necessary to identify the best genes and/or their regulatory components as mutation targets to avoid the mutation experiments being wasted on ineffective regions, but this goal is generally...

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Identifiers

PMID: 15454422
DOI: 10.1529/biophysj.104.044131
PMCID: PMC1304645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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