Article
Strain classification of Mycobacterium tuberculosis: congruence between large sequence polymorphisms and spoligotypes.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 1 Jan 2011
Kato-Maeda M, Gagneux S, Flores L L, Kim E Y, Small P M, Desmond E P, Hopewell P C
Abstract excerpt
Spoligotyping is used in molecular epidemiological studies, and signature patterns have identified strain families. However, homoplasy occurs in the markers used for spoligotyping, which could lead to identical spoligotypes in phylogenetically unrelated strains. We determined the accuracy of strain classification based on spoligotyping using the six large sequence and single nucleotide polymorphisms-defined...
Topics
- Bacterial Typing Techniques
- Humans
- Molecular Epidemiology
- Mycobacterium tuberculosis
- Polymorphism, Genetic
- Polymorphism, Single Nucleotide
- Retrospective Studies
- San Francisco
- Tuberculosis