Article
Acute myeloid leukemias with JAK2/STAT mutations are associated with PD-L1 upregulation.
Leukemia & lymphoma - 1 Oct 2023
Chai Jiani, Choudhuri Jui, Wang Qing, Fang Yanan, Shi Yang, Kamel Josette, Shah Nishi, Sica R Alejandro, Kornblum Noah, Konopleva Marina, Mantzaris Ioannis, Shastri Aditi, Gritsman Kira, Verma Amit, Goldfinger Mendel, Goel Swati, Wang Yanhua, Tian Xuejun
Abstract excerpt
Even though overexpression of the immune checkpoint protein, programmed cell death ligand-1 (PD-L1), is observed in solid tumors, its expression patterns in acute myeloid leukemia remain understudied. As activation of the JAK/STAT pathway has been shown to enhance PD-L1 expression in preclinical models, we evaluated biopsies from AML patients with activating mutations in JAK2/STATs. PD-L1 expression was...
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