Article
Combined genotype of HCRTR2 and CLOCK variants in a large family of cluster headache with familial periodicity phenotype.
Journal of neurology - 1 Oct 2023
Popescu Cyprian
Abstract excerpt
PURPOSE: Cluster headache (CH) is a debilitating condition with severe and recurrent headaches characterized by circannual and circadian rhythms. A genetic contingent was suggested, and several loci were described in large cohorts. However, no variant associated with CH for multiplex families has been described. The purpose of our study was to examine candidate genes and new genetic variants in a...
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