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Article

Genetic variability within molecular core clock genes in cluster headache.

Cephalalgia : an international journal of headache - 1 Apr 2026

Sanches Clémence Deborgies, Spulber Stefan, Olofsgård Felicia Jennysdotter, Fourier Carmen, Sundholm Anna, Lantz Maria, Sjöstrand Christina, Waldenlind Elisabet, Steinberg Anna, Houlden Henry, Matharu Manjit, Ran Caroline, Belin Andrea Carmine

Abstract excerpt

Background / HypothesisHeadache attacks are reported to occur with circadian rhythmicity by 2/3 of individuals with cluster headache, hinting to potential dysfunctions of the molecular clock. The aim of this study was to investigate the contribution of genetic markers in core clock genes, alone or in combinations, to the genetic risk for cluster headache.MethodsSeven markers in core clock genes BMAL1 and NPAS2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41967867
DOI: 10.1177/03331024261440136

Genes

NPAS2
BMAL1
CLOCK
CRY1
PER1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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