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Article

Intrathoracic synovial sarcoma with BRAF V600E mutation.

Oncotarget - 7 Jul 2023

Russo Ida, Barresi Sabina, Di Paolo Pier Luigi, Di Ruscio Valentina, Del Baldo Giada, Serra Annalisa, Vallese Silvia, Miele Evelina, Mastronuzzi Angela, Alaggio Rita, Ferrari Andrea, Milano Giuseppe Maria

Abstract excerpt

We report a case of 15-year-old boy with intrathoracic synovial sarcoma who relapsed after standard chemotherapy, surgery and radiotherapy. The molecular analysis of the tumour identified a BRAF V600E mutation at time of progression of relapsed disease under third line systemic treatment. This mutation is commonly seen in melanomas and papillary thyroid cancers, but less prevalent (typically <5%) across a variety...

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Identifiers

PMID: 37417899
DOI: 10.18632/oncotarget.28475
PMCID: PMC10327814

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