Article
BRAF mutations and concurrent alterations in patients with soft tissue sarcoma.
Genes, chromosomes & cancer - 1 Nov 2023
Kobayashi Hiroshi, Zhang Liuzhe, Okajima Koichi, Ishibashi Yuki, Hirai Toshihide, Tsuda Yusuke, Ikegami Masachika, Kage Hidenori, Shinozaki-Ushiku Aya, Oda Katsutoshi, Tanaka Sakae
Abstract excerpt
BRAF alterations, including V600E and non-V600E mutations and fusions, in soft tissue sarcoma (STS) have been identified in a limited case series. Here, we aimed to evaluate the frequency of BRAF mutations and concurrent alterations in STS to understand their therapeutic action. In this retrospective analysis, we included data from 1964 patients with advanced STS who underwent comprehensive genomic profiling...
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