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Article

Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability.

Nature communications - 6 Jul 2023

Movert Elin, Bolarin Jaume Salgado, Valfridsson Christine, Velarde Jorge, Skrede Steinar, Nekludov Michael, Hyldegaard Ole, Arnell Per, Svensson Mattias, Norrby-Teglund Anna, Cho Kyu Hong, Elhaik Eran, Wessels Michael R, Råberg Lars, Carlsson Fredric

Abstract excerpt

Variability in disease severity caused by a microbial pathogen is impacted by each infection representing a unique combination of host and pathogen genomes. Here, we show that the outcome of invasive Streptococcus pyogenes infection is regulated by an interplay between human STING genotype and bacterial NADase activity. S. pyogenes-derived c-di-AMP diffuses via streptolysin O pores into macrophages where it...

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Identifiers

PMID: 37414832
DOI: 10.1038/s41467-023-39771-0
PMCID: PMC10326033

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