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Targeting CDK4/6 suppresses colorectal cancer by destabilizing YAP1

17 Feb 2025

Abstract excerpt

Colorectal cancer (CRC) is among the most prevalent and deadly cancers worldwide. The Yes-associated protein 1 (YAP1) is frequently dysregulated in cancers, contributing to cancer stemness, chemoresistance, and cancer-related death. However, strategies directly targeting YAP1 have not yet been successful because of the lack of active binding pockets and unregulated toxicity. In this study, our Food and Drug...

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PMID: 39968498
DOI: 10.1002/mco2.70103

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