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Article

APOE genotypes modify the obesity paradox in dementia.

Journal of neurology, neurosurgery, and psychiatry - 1 Sept 2023

Shinohara Mitsuru, Gheni Ghupurjan, Hitomi Junichi, Bu Guojun, Sato Naoyuki

Abstract excerpt

BACKGROUND: While obesity in midlife is a risk factor for dementia, several studies suggested that obesity also protected against dementia, hence so-called obesity paradox. The current study aims to address the relationship between apolipoprotein E (APOE) genotype and obesity in dementia. METHODS: Clinical and neuropathological records of the National Alzheimer's Coordinating Center (NACC) in the USA, which...

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Identifiers

PMID: 37414536
DOI: 10.1136/jnnp-2022-331034
PMCID: PMC10695687

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