Is metabolic-healthy obesity associated with risk of dementia? An age-stratified analysis of the Whitehall II cohort study.

doi:10.1186/s12916-023-03155-4

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Article

Is metabolic-healthy obesity associated with risk of dementia? An age-stratified analysis of the Whitehall II cohort study.

BMC medicine - 14 Nov 2023

Machado-Fragua Marcos D, Sabia Séverine, Fayosse Aurore, Hassen Céline Ben, van der Heide Frank, Kivimaki Mika, Singh-Manoux Archana

Abstract excerpt

BACKGROUND: Metabolically healthy obesity is hypothesized to be a benign condition but whether this is the case for dementia remains debated. We examined the role of age at assessment of metabolic-obesity phenotypes in associations with incident dementia. METHODS: Obesity (body mass index ≥ 30 kg/m2) and poor metabolic health (≥ 2 of elevated serum triglycerides, low HDL-C, elevated blood pressure, and elevated...

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PMID: 37957712
DOI: 10.1186/s12916-023-03155-4
PMCID: PMC10644649

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