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Article

Analysis of neutral mutational drift in an allosteric enzyme.

Protein science : a publication of the Protein Society - 1 Aug 2023

Liechty Evan T, Hren Andrew, Kramer Levi, Donovan Gregory, Friedman Anika J, Shirts Michael R, Fox Jerome M

Abstract excerpt

Neutral mutational drift is an important source of biological diversity that remains underexploited in fundamental studies of protein biophysics. This study uses a synthetic transcriptional circuit to study neutral drift in protein tyrosine phosphatase 1B (PTP1B), a mammalian signaling enzyme for which conformational changes are rate limiting. Kinetic assays of purified mutants indicate that catalytic activity,...

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Identifiers

PMID: 37402140
DOI: 10.1002/pro.4719
PMCID: PMC10364584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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