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Article

Structural and mechanistic insights provided by single particle cryo-EM analysis of phosphoinositide 3-kinase (PI3Kα).

Biochimica et biophysica acta. Reviews on cancer - 1 Sept 2023

Vogt Peter K, Hart Jonathan R, Yang Su, Zhou Qingtong, Yang Dehua, Wang Ming-Wei

Abstract excerpt

Recent cryo-electron microscopic (cryo-EM) investigations have succeeded in the analysis of various structural conformations and functional states of PI3Kα, a dimer consisting of the catalytic subunit p110α and the regulatory subunit p85α of class IA of phosphoinositide 3-kinase. High resolution structures have been obtained of the unliganded and of BYL-719-bound PI3Kα. The latter provides information on...

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PMID: 37394020
DOI: 10.1016/j.bbcan.2023.188947
PMCID: PMC10530483

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