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Elevated NOX4 promotes tumorigenesis and acquired EGFR-TKIs resistance via enhancing IL-8/PD-L1 signaling in NSCLC.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Sept 2023

Liu Wen-Jing, Wang Lin, Zhou Feng-Mei, Liu Shu-Wen, Wang Wei, Zhao Er-Jiang, Yao Quan-Jun, Li Wei, Zhao Yan-Qiu, Shi Zhi, Qiu Jian-Ge, Jiang Bing-Hua

Abstract excerpt

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been widely used for human non-small-cell lung cancer (NSCLC) treatment. However, acquired resistance to EGFR-TKIs is the major barrier of treatment success, and new resistance mechanism remains to be elucidated. In this study, we found that elevated NADPH oxidase 4 (NOX4) expression was associated with acquired EGFR-TKIs resistance....

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Identifiers

PMID: 37392558
DOI: 10.1016/j.drup.2023.100987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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