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Article

Gefitinib analogue V1801 induces apoptosis of T790M EGFR-harboring lung cancer cells by up-regulation of the BH-3 only protein Noxa.

PloS one - 1 Jan 2012

Zhang Bo, Jiao Jiao, Liu Ying, Guo Liang-Xia, Zhou Bo, Li Gang-Qin, Yao Zhu-Jun, Zhou Guang-Biao

Abstract excerpt

Treatment of non-small cell lung cancer (NSCLC) with drugs targeting the epidermal growth factor receptor (EGFR), e.g., gefitinib and erlotinib, will eventually fail because of the development of secondary mutations such as T790M in EGFR. Strategies to overcome this resistance are therefore an urgent need. In this study, we synthesized a dozen of novel gefitinib analogues and evaluated their effects on...

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Identifiers

PMID: 23185274
DOI: 10.1371/journal.pone.0048748
PMCID: PMC3504066

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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