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A Novel Human AlkB Homologue, ALKBH8, Contributes to Human Bladder Cancer Progression

17 Mar 2009

Abstract excerpt

We recently identified a novel human AlkB homologue, ALKBH8, which is expressed in various types of human cancers including human urothelial carcinomas. In examining the role and function of ALKBH8 in human bladder cancer development in vitro, we found that silencing of ALKBH8 through small interfering RNA transfection reduced reactive oxygen species (ROS) production via down-regulation of NAD(P)H oxidase-1...

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PMID: 19293182
DOI: 10.1158/0008-5472.can-08-3530

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