Article
RNA design via structure-aware multifrontier ensemble optimization.
Bioinformatics (Oxford, England) - 30 Jun 2023
Zhou Tianshuo, Dai Ning, Li Sizhen, Ward Max, Mathews David H, Huang Liang
Abstract excerpt
MOTIVATION: RNA design is the search for a sequence or set of sequences that will fold to desired structure, also known as the inverse problem of RNA folding. However, the sequences designed by existing algorithms often suffer from low ensemble stability, which worsens for long sequence design. Additionally, for many methods only a small number of sequences satisfying the MFE criterion can be found by each run of...
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