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Association Study Identified HLA-DQA1 as a Novel Genetic Risk of Systemic Lupus Erythematosus-Associated Pulmonary Arterial Hypertension.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Dec 2023

Qian Junyan, Chen Ying, Yang Xinzhuang, Wang Qian, Zhao Jiuliang, Deng Xiaoyue, Ding Yufang, Li Shengjie, Liu Yongtai, Tian Zhuang, Shen Juan, Liao Qijun, Wang Yanhong, Zuo Xianbo, Zhang Xuejun, Li Mengtao, Cui Yong, Yu Xueqing, Zeng Xiaofeng

Abstract excerpt

OBJECTIVE: Pulmonary arterial hypertension (PAH) is a severe complication of systemic lupus erythematosus (SLE). However, the genetic signatures of SLE-associated PAH have not been well studied. We aimed to identify genetic variants implicated in SLE-associated PAH susceptibility within the major histocompatibility complex (MHC) region and assess the contribution to clinical outcomes. METHODS: A total of 172...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37382296
DOI: 10.1002/art.42641

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