Article
Using human genetics to understand the phenotypic association between chronotype and breast cancer.
Journal of sleep research - 1 May 2024
Wu Xueyao, Yang Chao, Zou Yanqiu, Jones Samuel E, Zhao Xunying, Zhang Li, Han Zhitong, Hao Yu, Xiao Jinyu, Xiao Chenghan, Zhang Wenqiang, Yan Peijing, Cui Huijie, Tang Mingshuang, Wang Yutong, Chen Lin, Zhang Ling, Yao Yuqin, Liu Zhenmi, Li Jiayuan, Jiang Xia, Zhang Ben
Abstract excerpt
Little is known regarding the shared genetic influences underlying the observed phenotypic association between chronotype and breast cancer in women. Leveraging summary statistics from the hitherto largest genome-wide association study conducted in each trait, we investigated the genetic correlation, pleiotropic loci, and causal relationship of chronotype with overall breast cancer, and with its subtypes defined...
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