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Article

Do sex hormones confound or mediate the effect of chronotype on breast and prostate cancer? A Mendelian randomization study.

PLoS genetics - 1 Jan 2022

Hayes Bryony L, Robinson Timothy, Kar Siddhartha, Ruth Katherine S, Tsilidis Konstantinos K, Frayling Timothy, Murray Anna, Martin Richard M, Lawlor Deborah A, Richmond Rebecca C

Abstract excerpt

Morning-preference chronotype has been found to be protective against breast and prostate cancer. Sex hormones have been implicated in relation to chronotype and the development of both cancers. This study aimed to assess whether sex hormones confound or mediate the effect of chronotype on breast and prostate cancer using a Mendelian Randomization (MR) framework. Genetic variants associated with chronotype and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35061662
DOI: 10.1371/journal.pgen.1009887
PMCID: PMC8809575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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