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The peroxisome proliferator-activated receptor γ coactivator-1 alpha rs8192678 (Gly482Ser) variant and hepatitis B virus clearance.

Infectious diseases (London, England) - 1 Sept 2023

Abounouh Karima, Tanouti Ikram-Allah, Ouladlahsen Ahd, Tahiri Mohamed, Badre Wafaa, Dehbi Hind, Sarih M'hammed, Benjelloun Soumaya, Pineau Pascal, Ezzikouri Sayeh

Abstract excerpt

BACKGROUND: Chronic hepatitis B virus (CHB) infection is still incurable a major public health problem. It is yet unclear how host genetic factors influence the development of HBV infection. The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) has been shown to regulate hepatitis B virus (HBV). Several reports found that PPARGC1A variants are involved in a number of distinct liver...

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PMID: 37376899
DOI: 10.1080/23744235.2023.2228403

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