Article
Reclassification of Splicing Gene Variants in Hereditary Cancer: Cases Report and Literature Review.
In vivo (Athens, Greece) - 1 Jan 2000
Bouzarelou Dimitra, Agiannitopoulos Konstantinos, Tsaousis Georgios N, Papadopoulou Eirini, Nasioulas George
Abstract excerpt
Alternative splicing (AS), a crucial cellular process, is a source of transcriptomic expansion and protein variability. Its contribution to cancer development and progression among a vast repertoire of human diseases, is highlighted lately and is under extensive investigation. In this review, the relative recent aspects of AS as a hallmark of cancer are described. In parallel, the importance of the identification...
Topics
- Humans
- Genetic Predisposition to Disease
- Alternative Splicing
- Neoplasms
- High-Throughput Nucleotide Sequencing