Article
Mutation goals in the vitamin D receptor predicted by computational methods.
The Journal of steroid biochemistry and molecular biology - 1 Oct 2018
Sicinska Wanda, Gront Dominik, Sicinski Kamil
Abstract excerpt
The mechanism through which nuclear receptors respond differentially to structurally distinct agonists is a poorly understood process. We present a computational method that identifies nuclear receptor amino acids that are likely involved in biological responses triggered by ligand binding. The method involves tracing how structural changes spread from the ligand binding pocket to the sites on the receptor...
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