Article

Calcium Dependent Conformational Changes in Human Transglutaminase 2 and its Implications in Celiac Disease

2025-06-07

Abstract excerpt

Transglutaminase 2 (TG2) serves as a modifiable transamidating acyltransferase that precipitates calcium-induced protein alterations. The enzyme plays a crucial role in the cell and disease states, such as tissue repair, calcium signal transduction, celiac disease, and cancer. It is implicated in protein crosslinking and has been found in high concentrations in the small intestines of those with celiac disease. Th...

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Literature Corpus work: 285553d2-8c5e-54d1-acbf-da4016de45dc
DOI: 10.1101/2025.06.04.657948

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