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Structural and functional insights into Vitamin D receptor mutations: An in-silico investigation of polymorphism-induced resistance.

Biophysical chemistry - 1 Apr 2026

Lohani Mohtashim, Khamjan Nizar Ahmad, Dar Sajad Ahmad, Aqil Farrukh, Khan Saif, Jawed Arshad, Beigh Saba, Ahmad Iffat Zareen

Abstract excerpt

Vitamin D is critical for calcium homeostasis, bone health, and immune regulation via the Vitamin D Receptor. Mutations in the ligand-binding domain and DNA-binding domain can disrupt ligand interactions, causing biologically active metabolite of vitamin D [1α,25-dihydroxyvitamin D3 (calcitriol)] resistance and clinical complications such as hereditary rickets and immune dysregulation. This study explored the...

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Binding Sites
Calcitriol
Molecular Docking Simulation
Molecular Dynamics Simulation
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation, Missense

Polymorphism, Genetic

Receptors, Calcitriol

Source

Identifiers

PMID: 41547173
DOI: 10.1016/j.bpc.2026.107579

Genes

VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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