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Article

Simvastatin rescues vascular health by targeting epigenetic-regulated endothelial-to-mesenchymal transition: a revival of pleiotropic effects?

8 Jun 2023

Abstract excerpt

Comment on the article ‘Statins improve endothelial function via suppression of epigenetic-driven EndMT’ published in Nature/Cardiovascular Research; doi.org/10.1038/s44161-023-00267-1. To investigate the effects of statins on endothelial function, Liu et al.1 generated human endothelial cells (ECs) derived from induced pluripotent stem cells (iPSC-ECs) from three healthy donors without familial...

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PMID: 37351620
DOI: 10.1093/eurheartj/ehad397

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