Article
CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes.
PLoS pathogens - 1 Aug 2006
Martin Diana L, Weatherly D Brent, Laucella Susana A, Cabinian Melissa A, Crim Matthew T, Sullivan Susan, Heiges Mark, Craven Sarah H, Rosenberg Charles S, Collins Matthew H, Sette Alessandro, Postan Miriam, Tarleton Rick L
Abstract excerpt
CD8+ T cells are crucial for control of a number of medically important protozoan parasites, including Trypanosoma cruzi, the agent of human Chagas disease. Yet, in contrast to the wealth of information from viral and bacterial infections, little is known about the antigen specificity or the general development of effector and memory T-cell responses in hosts infected with protozoans. In this study we report on a...
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