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Article

Identification of Trypanosoma cruzi trans-sialidase family members as targets of protective CD8+ TC1 responses

1 Dec 1997

Abstract excerpt

CD8+ T lymphocytes play a critical role in immunity to Trypanosoma cruzi. However, the target molecules of this T cell subset have not been elucidated. In this work, we report the identification of an H-2Kb-restricted CTL epitope within two trypomastigote surface Ags encoded by members of the T. cruzi sialidase/trans-sialidase gene superfamily. Octapeptide VDYNFTIV sensitized target cells for lysis by CD8+ CTL...

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PMID: 9550413
DOI: 10.4049/jimmunol.159.12.6120

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