Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic expression of the targeted null-mutation in the dopamine transporter gene varies as a function of the genetic background.

The European journal of neuroscience - 1 Jul 2004

Morice Elise, Denis Cécile, Giros Bruno, Nosten-Bertrand Marika

Abstract excerpt

The dopamine transporter (DAT) plays a critical role in calibrating the duration and intensity of dopamine (DA) neurotransmission. Mice in which the DAT gene has been genetically deleted exhibit constitutively high levels of extrasynaptic DA and spontaneous hyperactivity. Numerous studies have characterized the adaptive molecular, physiological, and behavioural consequences of abnormal DA neurotransmission in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cocaine
Share to Conditioning, Operant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine

Share to Dopamine Plasma Membrane Transport Proteins

Share to Dopamine Uptake Inhibitors

Share to Exploratory Behavior

Share to Maternal Behavior

Share to Motor Activity

Source

Identifiers

PMID: 15245485
DOI: 10.1111/j.1460-9568.2004.03465.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic expression of the targeted null-mutation in the dopamine transporter gene varies as a function of the genetic background.PMID 15245485Read ↗

Dopamine transporter mutant mice in experimental neuropharmacology.Semantic proximity Read ↗

The contribution of comparative studies in inbred strains of mice to the understanding of the hyperactive phenotype.Semantic proximity Read ↗

A genetic screen for behavioral mutations that perturb dopaminergic homeostasis in mice.Semantic proximity Read ↗

Influence of genetic background on alcohol drinking and behavioral phenotypes of 5-HT3 receptor over-expressing mice.Semantic proximity Read ↗

Characterization of a novel mouse model of Dopamine Transporter Deficiency Syndrome and pharmacological therapeutic strategiesSemantic proximity Read ↗

Locomotor Activity in D2 Dopamine Receptor-Deficient Mice Is Determined by Gene Dosage, Genetic Background, and Developmental AdaptationsSemantic proximity Read ↗

Mouse model of atypical DAT deficiency syndrome uncovers dopamine dysfunction associated with parkinsonism and psychiatric diseaseSemantic proximity Read ↗

Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasis.Semantic proximity Read ↗

Evidence of long-term expression of behavioral sensitization to both cocaine and ethanol in dopamine transporter knockout mice.Semantic proximity Read ↗

Congenic D1A dopamine receptor mutants: ethologically based resolution of behavioural topography indicates genetic background as a determinant of knockout phenotype.Semantic proximity Read ↗

The dopamine transporter: a crucial component regulating dopamine transmission.Semantic proximity Read ↗

Sex-Specific, Intermediate Behavioral Phenotypes in Heterozygous Dopamine Transporter Mutant DAT T356M Mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.