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Sex and Circuit Specific Dopamine Transporter Regulation Underlies Unique Behavioral Trajectories of Functional <i>SLC6A3</i> Coding Variation

2021-11-04

Abstract excerpt

Virtually all neuropsychiatric disorders display sex differences in prevalence, age of onset, and/or clinical symptomology. In sex-biased disorders, one sex is often suggested to harbor protective mechanisms, rendering them resilient to genetic and/or environmental risk factors. Here, we demonstrate sex-biased molecular, pharmacological and behavioral effects induced by the dopamine (DA) transporter (DAT) coding v...

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Literature Corpus work
a46df485-2f5c-5932-9c46-d2552b8eeccd
DOI
10.1101/2021.11.02.466932
Open publication

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