CD8+ T-cell Exhaustion Phenotype in Human Asymptomatic and Ocular Toxoplasmosis.

doi:10.1080/09273948.2023.2217906

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CD8+ T-cell Exhaustion Phenotype in Human Asymptomatic and Ocular Toxoplasmosis.

Ocular immunology and inflammation - 1 Sept 2024

García-López Laura Lorena, Vargas-Montes Mónica, Osorio-Méndez Juan Felipe, Cardona Néstor, Hernández De Los Ríos Alejandro, Toro-Acevedo Carlos Andrés, Arenas-García Juan Camilo, Mantilla-Muriel Luz Eliana, Torres Elizabeth, Valencia-Hernández Juan D, Acosta-Dávila Alejandro, de-la-Torre Alejandra, Celis-Giraldo Daniel, Mejía Oquendo Manuela, Sepúlveda-Arias Juan Carlos, Gómez-Marín Jorge Enrique

Abstract excerpt

This work analyzed exhaustion markers in CD8+ T-cell subpopulations in 21 samples of peripheral blood mononuclear cells (PBMCs) from individuals with ocular toxoplasmosis (n = 9), chronic asymptomatic toxoplasmosis (n = 7), and non-infected people (n = 5) by using RT-qPCR and flow cytometry techniques. The study found that gene expression of PD-1 and CD244, but not LAG-3, was higher in individuals with ocular...

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PMID: 37315178
DOI: 10.1080/09273948.2023.2217906

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