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A graph-based machine learning framework identifies critical properties of FVIII that lead to hemophilia A

10 May 2023

Abstract excerpt

Introduction: Blood coagulation is an essential process to cease bleeding in humans and other species. This mechanism is characterized by a molecular cascade of more than a dozen components activated after an injury to a blood vessel. In this process, the coagulation factor VIII (FVIII) is a master regulator, enhancing the activity of other components by thousands of times. In this sense, it is unsurprising that...

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PMID: 37235045
DOI: 10.3389/fbinf.2023.1152039

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