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Article

Analysis of clinical manifestations and molecular pathogenesis of six patients with hereditary blood coagulation factor VII deficiency.

Thrombosis research - 1 May 2025

Song Yu, Lu Yao, Miao Linzi, Li Yuanyuan, Jiang Anna, Qu Chenxue

Abstract excerpt

BACKGROUND: Hereditary blood coagulation factor VII (FVII) deficiency is a rare hemorrhagic disorder inherited in an autosomal recessive pattern, involving variants in the gene encoding FVII (F7). The sites and types of F7 mutations could influence the coagulation activity of plasma FVII (FVII: C) and the severity of hemorrhage symptoms. However, the specific molecular mechanisms of FVII deficiency are still...

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Identifiers

PMID: 40117674
DOI: 10.1016/j.thromres.2025.109304

Genes

F7

Variants

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