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Article

Deletion of Transferrin Receptor 1 in Parvalbumin Interneurons Induces a Hereditary Spastic Paraplegia-Like Phenotype.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Jul 2023

Xiong Wenchao, Jin Liqiang, Zhao Yulu, Wu Yu, Dong Jinghua, Guo Zhixin, Zhu Minzhen, Dai Yongfeng, Pan Yida, Zhu Xinhong

Abstract excerpt

Hereditary spastic paraplegia (HSP) is a severe neurodegenerative movement disorder, the underlying pathophysiology of which remains poorly understood. Mounting evidence has suggested that iron homeostasis dysregulation can lead to motor function impairment. However, whether deficits in iron homeostasis are involved in the pathophysiology of HSP remains unknown. To address this knowledge gap, we focused on...

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Identifiers

PMID: 37308296
DOI: 10.1523/JNEUROSCI.2277-22.2023
PMCID: PMC10325000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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