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Article

Late-onset of spinal neurodegeneration in knock-in mice expressing a mutant BiP.

PloS one - 1 Jan 2014

Jin Hisayo, Mimura Naoya, Kashio Makiko, Koseki Haruhiko, Aoe Tomohiko

Abstract excerpt

Most human neurodegenerative diseases are sporadic, and appear later in life. While the underlying mechanisms of the progression of those diseases are still unclear, investigations into the familial forms of comparable diseases suggest that endoplasmic reticulum (ER) stress is involved in the pathogenesis. Binding immunoglobulin protein (BiP) is an ER chaperone that is central to ER function. We produced knock-in...

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Identifiers

PMID: 25405877
DOI: 10.1371/journal.pone.0112837
PMCID: PMC4236098

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