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Article

A novel pyrosequencing strategy for RHD zygosity for predicting risk of hemolytic disease of the fetus and newborn.

Laboratory medicine - 7 Mar 2024

Lv Piao, Li Jixin, Yao Yuan, Fan Xinxin, Liu Chixiang, Li Hui, Zhou Huayou

Abstract excerpt

OBJECTIVE: The aim of this study was the development of an accurate and quantitative pyrosequence (PSQ) method for paternal RHD zygosity detection to help risk management of hemolytic disease of the fetus and newborn (HDFN). METHODS: Blood samples from 96 individuals were genotyped for RHD zygosity using pyrosequencing assay. To validate the accuracy of pyrosequencing results, all the samples were then detected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37307496
DOI: 10.1093/labmed/lmad051

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