RHD and RHCE genotyping by next-generation sequencing is an effective strategy to identify molecular variants within sickle cell disease patients.

doi:10.1016/j.bcmd.2017.03.014

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Article

RHD and RHCE genotyping by next-generation sequencing is an effective strategy to identify molecular variants within sickle cell disease patients.

Blood cells, molecules & diseases - 1 Jun 2017

Dezan Marcia R, Ribeiro Ingrid Helena, Oliveira Valéria B, Vieira Juliana B, Gomes Francisco C, Franco Lucas A M, Varuzza Leonardo, Ribeiro Roberto, Chinoca Karen Ziza, Levi José Eduardo, Krieger José Eduardo, Pereira Alexandre Costa, Gualandro Sandra F M, Rocha Vanderson G, Mendrone-Junior Alfredo, Sabino Ester Cerdeira, Dinardo Carla Luana

Abstract excerpt

BACKGROUND: The complexity of Rh genetic variation among sickle cell disease (SCD) patients is high. Conventional molecular assays cannot identify all genetic variants already described for the RH locus as well as foresee novel alleles. Sequencing RHD and RHCE is indicated to broaden the search for Rh genetic variants. AIMS: To standardize the Next Generation Sequencing (NGS) strategy to assertively identify Rh...

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Identifiers

PMID: 28388467
DOI: 10.1016/j.bcmd.2017.03.014

Genes

RHCE
RHD
SCD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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