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Article

Coiled coils ensure the physiological ectodomain shedding of collagen XVII.

The Journal of biological chemistry - 24 Aug 2012

Nishie Wataru, Jackow Joanna, Hofmann Silke C, Franzke Claus-Werner, Bruckner-Tuderman Leena

Abstract excerpt

α-Helical coiled coils, frequent protein oligomerization motifs, are commonly observed in vital proteins. Here, using collagen XVII as an example, we provide evidence for a novel function of coiled coils in the regulation of ectodomain shedding. Transmembrane collagen XVII, an epithelial cell surface receptor, mediates dermal-epidermal adhesion in the skin, and its dysfunction is linked to human skin blistering...

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Identifiers

PMID: 22761443
DOI: 10.1074/jbc.M112.345454
PMCID: PMC3436177

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