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Directed natural evolution generates a next-generation oncolytic virus with a high potency and safety profile

9 Jun 2023

Abstract excerpt

Oncolytic viruses (OVs) represent a type of encouraging multi-mechanistic drug for the treatment of cancer. However, attenuation of virulence, which is generally required for the development of OVs based on pathogenic viral backbones, is frequently accompanied by a compromised killing effect on tumor cells. By exploiting the property of viruses to evolve and adapt in cancer cells, we perform directed natural...

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PMID: 37296165
DOI: 10.1038/s41467-023-39156-3

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